The hottest Raman spectrum has unlimited potential

The potential of Raman spectroscopy is unlimited, and the application field adds great achievements.

Raman spectroscopy technology is highly respected in the field of basic research because of its advantages of non-destructive, convenient, high-speed, stable and so on. At present, this technology has been widely used in the fields of food safety, biomedicine, molecular structure research, chemical industry, archaeology and cultural relics identification. With the dedicated research of researchers, Raman spectroscopy technology is more mature and its application field is more in-depth

shift differential Raman spectroscopy technology has made a breakthrough

weak signal and easy interference can be described as the biggest problem limiting the application of Raman technology. In order to break through this bottleneck, researchers proposed displacement differential Raman spectroscopy (SERDs). However, there are still many problems in the practical application of the seemingly ideal technology, such as data deviation in the measurement process, algorithm selection and so on

recently, Nanjing Jianzhi Instrument Equipment Co., Ltd. (hereinafter referred to as Jianzhi instrument) released the first portable differential Raman spectroscopy in China. Jane Zhi instrument has studied the displacement differential Raman spectroscopy technology for many years. As the research result of this technology, the device innovatively adopts the BP neural network technology. Based on the principle that any function can be approximated by a network with three-layer units with arbitrary accuracy (cybenko 1988), the difference, alignment and baseline correction are completed at the same time by means of iterative optimal solution. This equipment can be used to directly measure high fluorescent substances, greatly improving the detection sensitivity and signal-to-noise ratio of the whole system. At the same time, it can filter out the interference peak and only retain the pure Raman peak, which is convenient for researchers to carry out theoretical research

Raman spectroscopy helps epigenetic rapid sequencing

epigenetics is one of the most cutting-edge fields in genetic research. The currently used epigenetic test using a cotton swabbing machine before and after each use has the disadvantages of cumbersome, time-consuming, expensive and so on. On May 9, the Belgian intercollegiate Microelectronics Center (IMEC) issued a bulletin, saying that the center has successfully developed a new optical nanopore device that can directly read single molecular DNA bases, which is expected to be used for rapid sequencing in genetic research

it is reported that the new device uses surface enhanced Raman spectroscopy and nanopore fluid technology. Nanofluid technology will drive DNA molecules to pass through the surface plasma nano slit. At the moment of passing through, surface enhanced Raman spectroscopy will be excited and "draw" the "fingerprint" of base molecules, so as to achieve accurate identification of chemical bonds. Through the near daily use of surface enhanced Raman spectroscopy and nanoporous fluid technology, this nanoporous device can not only "read" DNA coding, but also "read" various chemical modification products of bases. These modified products usually carry a lot of information related to epigenetic variation and affect gene expression in cells. It is of great significance to observe these modified products

SERRS technology is applied to catecholamine detection

as an important acupuncture effect substance, the supplier of catecholamine will make troubleshooting plans for users within 12 hours and inform users that catecholamine plays an important role in life. At present, the detection methods of catecholamine are diverse. However, due to its complex environment, low content and easy oxidation, the detection results are not ideal. Recently, a large number of scholars from the Institute of intelligent machinery, Hefei academy of material sciences, Chinese Academy of sciences are still working hard. Yang Liangbao, a researcher of the Institute, and others have used surface resonance enhanced Raman spectroscopy (SERRS) technology to detect catecholamine acupuncture effect substances in serum

in the research process, researchers combined the target molecules with weak surface enhanced Raman spectroscopy (SERS) activity with Raman probes, which significantly improved the Raman scattering spectral intensity of the target molecules. In addition, the multi-component detection of catecholamines in serum can be realized by using the advantages of algorithm and SERS fingerprint recognition. Further using the au-0 bond of the functionalized substrate as the internal standard signal, catecholamines at low concentrations can be quantitatively detected

with the deepening of research, Raman spectroscopy technology is becoming more and more mature, and gradually began to play a role in many fields. Now, the research progress of Raman spectroscopy in various countries is accelerating. We believe that this non-destructive intelligent detection technology will release vitality in more fields and promote fruitful results in other research fields